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Geral 2025
DOI: 10.1016/j.jped.2025.03.003

Cutoff levels for newborn screening of 21-OH deficiency in a Brazilian metropolitan area

Autores: Kallianna Paula Duarte Gameleira, Juliana de Vasconcellos Thomas, Vitor Guilherme Brito de Araújo et al.

To evaluate the accuracy of neonatal 17-hydroxyprogesterone (N17OHP) levels adjusted for birth weight (BW) and time of the sample collection (TC) and propose optimized cutoff values to improve the effectiveness of newborn screening tests for...

Geral Nov 2025
DOI: 10.1590/1413-812320253010.09432025

Burn deaths in Brazil: a social issue

Autores: Sérgio Eduardo Soares Fernandes, Derek Chaves Lopes, Erik Teixeira Lopes et al.

This study explores the relationship between socioeconomic and geographic variables of Brazilian municipalities and deaths caused by thermal (TB) and electrical burns (EB). Using data from the Mortality Information System and municipal indicators from IBGE,...

Geral Oct 2025
DOI: 10.1097/MD.0000000000045015

Experience with flash glucose monitoring: Impact on glycemic control and quality of life in type 1 diabetes within a public healthcare program

Autores: Betyna Saldanha Corbal, Rafaela Flavia da Silva Puzic, Erica Tatiane da Silva et al.

Flash glucose monitoring (FGM) systems provide real-time interstitial glucose readings and offer a reliable alternative to capillary self-monitoring of blood glucose. This technology may improve diabetes management and quality of life (QoL) for individuals with...

Geral May 2025
DOI: 10.1016/j.vhri.2025.101084

Cost-Effectiveness of Mineralocorticoid Receptor Antagonists in Ischemic and Nonischemic Heart Failure With Reduced Ejection Fraction: Perspective From a Universal Healthcare System

Autores: Cristiane Koeche, Ana Claudia Cavalcante Nogueira, Giselle Pinto da Silva Amaral et al.

Mineralocorticoid receptor antagonists (MRAs) are cornerstones in the management of heart failure (HF) with reduced ejection fraction (HFrEF). New MRAs with improved safety profile, such as finerenone and eplerenone, were recently introduced. However, because of...

Geral 2025
DOI: 10.1590/S0004-2803.24612025-034

TRANSLATION, CULTURAL ADAPTATION, AND SEMANTIC VALIDATION OF THE PEDIATRIC NEUROGENIC BOWEL DYSFUNCTION SCORE (NDBS) INTO BRAZILIAN PORTUGUESE AND A PILOT STUDY

Autores: Lenamaris Mendes Rocha Duarte, Ana Lúcia Ribeiro Salomon, Carmelia Matos Santiago Reis

This study aimed to translate the Neurogenic Bowel Dysfunction Score into Brazilian Portuguese, adapting it culturally and validating it semantically. The process followed international guidelines for translation, back-translation, cultural adaptation, and semantic validation, involving a...

Geral Dec 2025
DOI: 10.12659/MSM.950488

COVID-19 on Elective Surgery Outcomes in a Brazilian Tertiary Hospital: A Retrospective Cohort Study

Autores: Dilson Palhares Ferreira, Cláudia Vicari Bolognani, Luana Argollo Souza Fernandes et al.

BACKGROUND The COVID-19 pandemic significantly disrupted elective surgical services worldwide, especially in resource-limited settings, raising concerns about surgical safety and care quality. This study compared postoperative hospital mortality, day-of-surgery cancellations, and surgical reintervention rates before,...

Geral 2025
DOI: 10.1016/j.ric.2025.100030

Efficacy and safety of delayed thrombolysis for ischemic stroke within 4.5-24h: A systematic review and meta-analysis of randomized controlled trials

Autores: Jesús Fernando Briceño-Domínguez, Grecia Bejarano-Carabeo, Rodrigo Góes de Oliveira Galvão et al.

The efficacy and safety of thrombolytics within the first 4.5h of ischemic stroke symptom onset are well documented; however, evidence beyond this timeframe remains contentious. To assess the efficacy and safety of delayed thrombolysis (4.5-24-h...

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